Pub. Date : 2016 May 10
PMID : 27114540
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, recent discoveries focused attention on CFTR-mediated HCO3 (-) secretion and airway surface liquid (ASL) pH as critical for host defense and CF pathogenesis. | Bicarbonates | CF transmembrane conductance regulator | Homo sapiens |
| 2 | Likewise, heterozygous epithelia (CFTR(+/-) or CFTR(+/ F508)) expressed CFTR and secreted HCO3 (-) at ~50% of wild-type values. | Bicarbonates | CF transmembrane conductance regulator | Homo sapiens |
| 3 | Likewise, heterozygous epithelia (CFTR(+/-) or CFTR(+/ F508)) expressed CFTR and secreted HCO3 (-) at ~50% of wild-type values. | Bicarbonates | CF transmembrane conductance regulator | Homo sapiens |
| 4 | Likewise, heterozygous epithelia (CFTR(+/-) or CFTR(+/ F508)) expressed CFTR and secreted HCO3 (-) at ~50% of wild-type values. | Bicarbonates | CF transmembrane conductance regulator | Homo sapiens |
| 5 | Overexpressing CFTR increased HCO3 (-) secretion to rates greater than wild type, but ASL pH did not exceed wild-type values. | Bicarbonates | CF transmembrane conductance regulator | Homo sapiens |
| 6 | Thus, in contrast to Cl(-) secretion, the amount of CFTR is rate-limiting for HCO3 (-) secretion and for correcting host defense abnormalities. | Bicarbonates | CF transmembrane conductance regulator | Homo sapiens |