Title : Combined metformin and resveratrol confers protection against UVC-induced DNA damage in A549 lung cancer cells via modulation of cell cycle checkpoints and DNA repair.

Pub. Date : 2016 Jun

PMID : 27109601






2 Functional Relationships(s)
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1 We found that metformin inhibited UVC-induced upregulation of p53, as well as downregulated the expression of two DNA damage markers: gammaH2AX and p-chk2. Metformin tumor protein p53 Homo sapiens
2 However, resveratrol displayed synergism when combined with metformin as shown by the downregulation of p53/gammaH2AX/p-chk2. Metformin tumor protein p53 Homo sapiens