Pub. Date : 2016 Jun
PMID : 27108527
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased interleukin-6 expression is associated with poor prognosis and acquired cisplatin resistance in head and neck squamous cell carcinoma. | Cisplatin | interleukin 6 | Homo sapiens |
| 2 | Similar tendency was observed in platinum treated patients, suggesting an IL-6 associated cisplatin resistance. | Cisplatin | interleukin 6 | Homo sapiens |
| 3 | IL-6 increase was also found in two in-house acquired cisplatin-resistant HNSCC cell lines (both basaloid and conventional squamous cell carcinoma) by using microarray analysis. | Cisplatin | interleukin 6 | Homo sapiens |
| 4 | However, although the in-house acquired cisplatin-resistant cell lines had higher basal and markedly increased cisplatin-induced IL-6 expression, IL-6 did not mediate the cisplatin resistance as neither exogenous IL-6 nor IL-6R/gp130 inhibitors affected cisplatin sensitivity. | Cisplatin | interleukin 6 | Homo sapiens |
| 5 | However, although the in-house acquired cisplatin-resistant cell lines had higher basal and markedly increased cisplatin-induced IL-6 expression, IL-6 did not mediate the cisplatin resistance as neither exogenous IL-6 nor IL-6R/gp130 inhibitors affected cisplatin sensitivity. | Cisplatin | interleukin 6 | Homo sapiens |
| 6 | However, although the in-house acquired cisplatin-resistant cell lines had higher basal and markedly increased cisplatin-induced IL-6 expression, IL-6 did not mediate the cisplatin resistance as neither exogenous IL-6 nor IL-6R/gp130 inhibitors affected cisplatin sensitivity. | Cisplatin | interleukin 6 | Homo sapiens |
| 7 | However, although the in-house acquired cisplatin-resistant cell lines had higher basal and markedly increased cisplatin-induced IL-6 expression, IL-6 did not mediate the cisplatin resistance as neither exogenous IL-6 nor IL-6R/gp130 inhibitors affected cisplatin sensitivity. | Cisplatin | interleukin 6 | Homo sapiens |
| 8 | Thus, high IL-6 expression correlated to poor prognosis and acquired cisplatin resistance, but it did not mediate cisplatin resistance in the HNSCC cell lines. | Cisplatin | interleukin 6 | Homo sapiens |