Title : Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and β-secretase 1 inhibitors.

Pub. Date : 2016 Jun

PMID : 27106028






2 Functional Relationships(s)
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1 We evaluated the major active components isolated from Corni Fructus: loganin, morroniside, and 7-O-galloyl-D-sedoheptulose as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) for use in Alzheimer"s disease treatment. 7-O-galloyl-D-sedoheptulose acetylcholinesterase (Cartwright blood group) Homo sapiens
2 We evaluated the major active components isolated from Corni Fructus: loganin, morroniside, and 7-O-galloyl-D-sedoheptulose as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) for use in Alzheimer"s disease treatment. 7-O-galloyl-D-sedoheptulose acetylcholinesterase (Cartwright blood group) Homo sapiens