Title : Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter.

Pub. Date : 2016 Apr 19

PMID : 27089947






1 Functional Relationships(s)
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1 We employ ultraviolet-induced crosslinking with p-azido-L-phenylalanine (azF) at selected positions in hSERT to map the binding site of imipramine, a prototypical tricyclic antidepressant, and vortioxetine, a novel multimodal antidepressant. Imipramine AZF1 Homo sapiens