Pub. Date : 2016 Apr 14
PMID : 27075303
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury. | Alcohols | carboxylesterase 1 | Homo sapiens |
| 2 | Alcohol repressed both HNF4alpha and CES1 expression in primary hepatocytes. | Alcohols | carboxylesterase 1 | Homo sapiens |
| 3 | Global inactivation of CES1 aggravated alcohol- or MCD diet-induced liver inflammation and liver injury, likely as a result of increased production of acetaldehyde and reactive oxygen species and mitochondrial dysfunctions. | Alcohols | carboxylesterase 1 | Homo sapiens |
| 4 | These data indicate that CES1 plays a crucial role in protection against alcohol- or MCD diet-induced liver injury. | Alcohols | carboxylesterase 1 | Homo sapiens |