Title : Amitriptyline protects against TNF-α-induced atrophy and reduction in synaptic markers via a Trk-dependent mechanism.

Pub. Date : 2016 Apr

PMID : 27069625






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1 Furthermore, pretreatment of primary cortical neurons with amitriptyline and nortriptyline prevents the effects of the proinflammatory cytokine TNF-alpha (10 ng/mL) on neurite outgrowth and colocalization of synaptic proteins. Nortriptyline tumor necrosis factor Rattus norvegicus