Title : Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.

Pub. Date : 2016 Jul 1

PMID : 27063099






2 Functional Relationships(s)
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1 Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry. Calcium angiotensin converting enzyme 2 Homo sapiens
2 Mechanistically, ACE2/Ang-(1-7)/Mas axis activation inhibits store-operated calcium entry (SOCE) and PAK1/NF-kappaB/Snail1 pathways, and induces E-cadherin expression. Calcium angiotensin converting enzyme 2 Homo sapiens