Title : Exogenous C2 Ceramide Suppresses Matrix Metalloproteinase Gene Expression by Inhibiting ROS Production and MAPK Signaling Pathways in PMA-Stimulated Human Astroglioma Cells.

Pub. Date : 2016 Mar 31

PMID : 27043542






1 Functional Relationships(s)
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1 Furthermore, C2 ceramide significantly inhibited PMA-induced reactive oxygen species (ROS) production and NADPH oxidase 4 (NOX4) expression, and inhibition of ROS by diphenylene iodonium (DPI, NADPH oxidase inhibitor) mimicked the effects of C2 ceramide on MMP expression and NF-kappaB/AP-1 via inhibition of p38 MAPK. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens