Title : Lon protease and eiF2α are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells.

Pub. Date : 2016 May 25

PMID : 27041070






2 Functional Relationships(s)
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1 We previously showed the nucleoside analogues (NRTIs), Zidovudine (AZT; 7.1 muM), Stavudine (d4T; 4 muM), and Tenofovir (TFV; 1.2 muM) induced oxidative stress and mitochondrial dysfunction in human hepatoma (HepG2) cells at 24 h (h) and 120 h. We conducted a mitochondrial proteomic assessment of homeostasis in the same model, using the same NRTIs. Zidovudine latexin Homo sapiens
2 We previously showed the nucleoside analogues (NRTIs), Zidovudine (AZT; 7.1 muM), Stavudine (d4T; 4 muM), and Tenofovir (TFV; 1.2 muM) induced oxidative stress and mitochondrial dysfunction in human hepatoma (HepG2) cells at 24 h (h) and 120 h. We conducted a mitochondrial proteomic assessment of homeostasis in the same model, using the same NRTIs. Zidovudine latexin Homo sapiens