Title : Hyperglycemia Suppresses Calcium Phosphate-Induced Aneurysm Formation Through Inhibition of Macrophage Activation.

Pub. Date : 2016 Mar 28

PMID : 27021877






1 Functional Relationships(s)
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1 Activation of Nr1h2 by the antagonist GW3965 during stimulation with TNF-alpha plus CaPO4 mimicked hyperglycemic conditions and inhibited Mmp9 upregulation, whereas the deactivation of Nr1h2 by small interfering RNA (siRNA) under hyperglycemic conditions canceled the suppressive effect and restored Mmp9 expression induced by TNF-alpha plus CaPO4. GW 3965 matrix metallopeptidase 9 Mus musculus