Title : Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP.

Pub. Date : 2016 Jun

PMID : 27001813






2 Functional Relationships(s)
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1 Fifty percent inhibitory concentrations (IC50s) for P-gp and BCRP were both 2 muM for itraconazole, 5 and 12 muM for hydroxyitraconazole, 3 and 6 muM for posaconazole, and 3 and 11 muM for isavuconazole, respectively. Itraconazole latexin Homo sapiens
2 BSEP was strongly inhibited by itraconazole and hydroxyitraconazole (3 and 17 muM, respectively). Itraconazole latexin Homo sapiens