Title : Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice.

Pub. Date : 2016 Jun

PMID : 26996132






3 Functional Relationships(s)
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1 Treatment with DFO efficiently alleviated behavioral deficits, increased the survival of tyrosine hydroxylase (TH)-positive neurons, and decreased the action of astrocytes in the SN and striatum in an MPTP-induced PD mouse model. Deferoxamine tyrosine hydroxylase Mus musculus
2 Treatment with DFO efficiently alleviated behavioral deficits, increased the survival of tyrosine hydroxylase (TH)-positive neurons, and decreased the action of astrocytes in the SN and striatum in an MPTP-induced PD mouse model. Deferoxamine tyrosine hydroxylase Mus musculus
3 Interestingly, we found that DFO up-regulated the expression of HIF-1alpha protein, TH, vascular endothelial growth factor (VEGF), and growth associated protein 43 (GAP43) and down-regulated the expression of alpha-synuclein, divalent metal transporter with iron-responsive element (DMT1+IRE), and transferrin receptor (TFR). Deferoxamine tyrosine hydroxylase Mus musculus