Title : Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice.

Pub. Date : 2016 Jun

PMID : 26996132






3 Functional Relationships(s)
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1 Deferoxamine-mediated up-regulation of HIF-1alpha prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice. Deferoxamine mitogen-activated protein kinase 1 Homo sapiens
2 We further revealed that DFO treatment significantly inhibited the MPTP-induced phosphorylation of the c-Jun N-terminal kinase (JNK) and differentially enhanced the phosphorylation of extracellular regulated protein kinases (ERK) and mitogen-activated protein kinase (MAPK)/P38 kinase. Deferoxamine mitogen-activated protein kinase 1 Homo sapiens
3 In SH-SY5Y cells, the DFO-mediated up-regulation of HIF-1alpha occurred via the activation of the ERK and P38MAPK signaling pathway. Deferoxamine mitogen-activated protein kinase 1 Homo sapiens