Pub. Date : 2016 May
PMID : 26992777
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 2 | Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 3 | Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 4 | Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 5 | OBJECTIVES: This study aimed to investigate the protective role of heme oxygenase-1 (HO-1) in H2O2-induced oxidative stress and apoptosis in human lens epithelial cells (hLEC; SRA01/04). | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 6 | OBJECTIVES: This study aimed to investigate the protective role of heme oxygenase-1 (HO-1) in H2O2-induced oxidative stress and apoptosis in human lens epithelial cells (hLEC; SRA01/04). | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 7 | RESULTS: HO-1 significantly restored the cell viability under H2O2 injury via reducing the generation of ROS and increasing the levels of SOD and GSH activity. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 8 | Moreover, HO-1 also inhibited H2O2-induced caspase-8 and caspase-3 proteins, thus significantly reducing the apoptosis of SRA01/04. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 9 | CONCLUSIONS: These findings suggested that HO-1 protects human lens epithelial cells from H2O2-induced oxidant stress by upregulating antioxidant enzyme activity, reducing ROS generation, and thus inhibiting caspase family-dependent apoptosis. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |