Title : Effect of IGF-I and TNF-α on intensification of steroid pathways in women with PCOS phenotypes are not identical. Enhancement of progesterone pathway in women with PCOS increases the concentration of TNF-α.

Pub. Date : 2016 Sep

PMID : 26979943






1 Functional Relationships(s)
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1 Inflammatory state involving TNF-alpha in women with PCOS and high concentration of androgens is caused by intensified Delta4 (progesterone) pathway and omitted or limited Delta5 (dehydroepiandrosterone) pathway of testosterone biosynthesis. Progesterone tumor necrosis factor Homo sapiens