Title : Biological Significance of Mutant Isocitrate Dehydrogenase 1 and 2 in Gliomagenesis.

Pub. Date : 2016

PMID : 26960449






2 Functional Relationships(s)
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Protein Name
Organism
1 While IDH1 and IDH2 catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (alpha-KG), IDH1 and IDH2 mutations convert alpha-KG to 2-hydroxyglutarate (2-HG). isocitric acid isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens
2 While IDH1 and IDH2 catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (alpha-KG), IDH1 and IDH2 mutations convert alpha-KG to 2-hydroxyglutarate (2-HG). isocitric acid isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens