Title : Do testosterone and estradiol-17 beta enforce inhibition or stimulation of luteinizing hormone-releasing hormone secretion?

Pub. Date : 1989 Oct

PMID : 2695172






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The effects of gonadectomy and gonadal steroid replacement on hypothalamic luteinizing hormone-releasing hormone (LHRH) secretion in vivo and in vitroi in the rat are reviewed. Steroids gonadotropin releasing hormone 1 Rattus norvegicus
2 The effects of gonadectomy and gonadal steroid replacement on hypothalamic luteinizing hormone-releasing hormone (LHRH) secretion in vivo and in vitroi in the rat are reviewed. Steroids gonadotropin releasing hormone 1 Rattus norvegicus
3 There is little evidence to date to corroborate the assumptions that the rate of hypothalamic LHRH drive is enhanced to sustain the post-gonadectomy LH response and that gonadal steroids inhibit LHRH secretion in gonadectomized rats. Steroids gonadotropin releasing hormone 1 Rattus norvegicus
4 There is a dire need to develop newer techniques not only to characterize the LHRH pulsatility pattern reaching the pituitary gonadotropes on a moment-to-moment basis but also to fully explain the existing evidence that suggests a facilitatory influence of gonadal steroids and invokes participation of newer neural and steroidal and nonsteroidal gonadal factors in regulating the communication between LHRH secreting neurons and pituitary gonadotropes. Steroids gonadotropin releasing hormone 1 Rattus norvegicus