Title : BDNF acting in the hypothalamus induces acute pressor responses under permissive control of angiotensin II.

Pub. Date : 2016 May

PMID : 26948539






2 Functional Relationships(s)
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1 In conscious rats, unilateral BDNF (12.5ng) microinjections into the PVN increased mean arterial pressure (MAP) by 27+-1mmHg (P<0.001 vs vehicle), which was significantly attenuated by intracerebroventricular infusion of the Ang II-type-1 receptor (AT1R) antagonist losartan and by ganglionic blockade with intravenous hexamethonium infusion. Hexamethonium brain-derived neurotrophic factor Rattus norvegicus
2 In anesthetized rats, unilateral PVN microinjection of BDNF increased MAP by 31+-4mmHg (P<0.001 vs vehicle), which was prevented by PVN microinjection pretreatments with the high-affinity BDNF receptor TrkB antagonist ANA-12, losartan, the angiotensin converting enzyme inhibitor lisinopril, or by intravenous hexamethonium. Hexamethonium brain-derived neurotrophic factor Rattus norvegicus