Pub. Date : 2016 Jun
PMID : 26944919
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Edelfosine Promotes Apoptosis in Androgen-Deprived Prostate Tumors by Increasing ATF3 and Inhibiting Androgen Receptor Activity. | edelfosine | activating transcription factor 3 | Homo sapiens |
| 2 | Furthermore, edelfosine treatment inhibited the expression of androgen receptor (AR) and was associated with an increase in activating transcription factor 3 (ATF3) expression levels, a stress response gene and a negative regulator of AR transactivation. | edelfosine | activating transcription factor 3 | Homo sapiens |
| 3 | Furthermore, edelfosine treatment inhibited the expression of androgen receptor (AR) and was associated with an increase in activating transcription factor 3 (ATF3) expression levels, a stress response gene and a negative regulator of AR transactivation. | edelfosine | activating transcription factor 3 | Homo sapiens |
| 4 | ATF3 binds to AR after edelfosine + AD and represses the transcriptional activation of AR as demonstrated by PSA promoter studies. | edelfosine | activating transcription factor 3 | Homo sapiens |
| 5 | Knockdown of ATF3 using siRNA-ATF3 reversed the inhibition of PSA promoter activity, suggesting that the growth inhibition effect of edelfosine was ATF3 dependent. | edelfosine | activating transcription factor 3 | Homo sapiens |
| 6 | Knockdown of ATF3 using siRNA-ATF3 reversed the inhibition of PSA promoter activity, suggesting that the growth inhibition effect of edelfosine was ATF3 dependent. | edelfosine | activating transcription factor 3 | Homo sapiens |
| 7 | Knockdown of ATF3 using siRNA-ATF3 reversed the inhibition of PSA promoter activity, suggesting that the growth inhibition effect of edelfosine was ATF3 dependent. | edelfosine | activating transcription factor 3 | Homo sapiens |