Pub. Date : 2016 Mar 4
PMID : 26940749
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, whether lysine acetylation at position 280 (K280) modulates hTau-induced toxicity in vivo is unknown. | argatroban | microtubule associated protein tau | Homo sapiens |
| 2 | In addition, modulation of K280 influenced total hTau levels and phosphorylation without changing hTau solubility. | argatroban | microtubule associated protein tau | Homo sapiens |
| 3 | Altogether, our results indicate that pseudo-acetylation of the single K280 residue is sufficient to exacerbate hTau neurotoxicity in vivo, suggesting that acetylated K280-hTau species contribute to the pathological events leading to neurodegeneration in AD. | argatroban | microtubule associated protein tau | Homo sapiens |
| 4 | Altogether, our results indicate that pseudo-acetylation of the single K280 residue is sufficient to exacerbate hTau neurotoxicity in vivo, suggesting that acetylated K280-hTau species contribute to the pathological events leading to neurodegeneration in AD. | argatroban | microtubule associated protein tau | Homo sapiens |