Pub. Date : 2016 May
PMID : 26937021
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1. | tazarotenic acid | cytochrome P450 family 26 subfamily B member 1 | Homo sapiens |
| 2 | The CYP26A1 and CYP26B1 homology models predicted that the benzothiopyranyl moiety of tazarotenic acid would be oriented toward the heme of each enzyme and suggested that tazarotenic acid would be a substrate of CYP26A1 and CYP26B1. | tazarotenic acid | cytochrome P450 family 26 subfamily B member 1 | Homo sapiens |
| 3 | The CYP26A1 and CYP26B1 homology models predicted that the benzothiopyranyl moiety of tazarotenic acid would be oriented toward the heme of each enzyme and suggested that tazarotenic acid would be a substrate of CYP26A1 and CYP26B1. | tazarotenic acid | cytochrome P450 family 26 subfamily B member 1 | Homo sapiens |
| 4 | The CYP26A1 and CYP26B1 homology models predicted that the benzothiopyranyl moiety of tazarotenic acid would be oriented toward the heme of each enzyme and suggested that tazarotenic acid would be a substrate of CYP26A1 and CYP26B1. | tazarotenic acid | cytochrome P450 family 26 subfamily B member 1 | Homo sapiens |
| 5 | The CYP26A1 and CYP26B1 homology models predicted that the benzothiopyranyl moiety of tazarotenic acid would be oriented toward the heme of each enzyme and suggested that tazarotenic acid would be a substrate of CYP26A1 and CYP26B1. | tazarotenic acid | cytochrome P450 family 26 subfamily B member 1 | Homo sapiens |
| 6 | Metabolite identification experiments indicated that CYP26A1 and CYP26B1 oxidatively metabolized tazarotenic acid on the predicted moiety, with in vitro rates of metabolite formation by CYP26A1 and CYP26B1 being the highest across a panel of enzymes. | tazarotenic acid | cytochrome P450 family 26 subfamily B member 1 | Homo sapiens |
| 7 | Metabolite identification experiments indicated that CYP26A1 and CYP26B1 oxidatively metabolized tazarotenic acid on the predicted moiety, with in vitro rates of metabolite formation by CYP26A1 and CYP26B1 being the highest across a panel of enzymes. | tazarotenic acid | cytochrome P450 family 26 subfamily B member 1 | Homo sapiens |
| 8 | Overall, the homology models presented herein describe the enzyme characteristics leading to the metabolism of tazarotenic acid by CYP26A1 and CYP26B1 and support a potential role for the CYP26 enzymes in the metabolism of xenobiotics. | tazarotenic acid | cytochrome P450 family 26 subfamily B member 1 | Homo sapiens |