Title : Downregulation of vascular endothelial growth factor receptor-2 under oxidative stress conditions is mediated by β-transduction repeat-containing protein via glycogen synthase kinase-3β signaling.

Pub. Date : 2016 Apr

PMID : 26935904






3 Functional Relationships(s)
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1 However, VEGFR-2 was reduced when directly exposed to ROS, with resultant co-location of beta-TrCP and VEGFR-2. Reactive Oxygen Species beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens
2 Decreased VEGFR-2 caused by ROS was ameliorated by beta-TrCP siRNA, proteasome inhibitor MG132 and GSK-3beta activity inhibitor (lithium chloride and SB216763). Reactive Oxygen Species beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens
3 We suggest that redundant ROS reduces VEGFR-2 through beta-TrCP-mediated VEGFR-2 degradation, which is postulated to be regulated by GSK-3beta. Reactive Oxygen Species beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens