Title : Thiopurine Biotransformation and Pharmacological Effects: Contribution of Oxidative Stress.

Pub. Date : 2016

PMID : 26935390






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Thiopurines are catabolized in the liver by xanthine oxidase, with potential production of reactive oxidative species and azathioprine is converted into mercaptopurine by a reaction with reduced glutathione, that, in some tissues, may be facilitated by glutathione- S-transferase (GST). Mercaptopurine glutathione S-transferase kappa 1 Homo sapiens
2 Thiopurines are catabolized in the liver by xanthine oxidase, with potential production of reactive oxidative species and azathioprine is converted into mercaptopurine by a reaction with reduced glutathione, that, in some tissues, may be facilitated by glutathione- S-transferase (GST). Mercaptopurine glutathione S-transferase kappa 1 Homo sapiens