Title : Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects.

Pub. Date : 2016 Nov

PMID : 26931777






3 Functional Relationships(s)
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1 Based upon in vitro studies, the potential for LCZ696 to inhibit or induce cytochrome P450 (CYP) enzymes and cause CYP-mediated drug interactions clinically was found to be low. sacubitril and valsartan sodium hydrate drug combination cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Based upon in vitro studies, the potential for LCZ696 to inhibit or induce cytochrome P450 (CYP) enzymes and cause CYP-mediated drug interactions clinically was found to be low. sacubitril and valsartan sodium hydrate drug combination cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 Based upon in vitro studies, the potential for LCZ696 to inhibit or induce cytochrome P450 (CYP) enzymes and cause CYP-mediated drug interactions clinically was found to be low. sacubitril and valsartan sodium hydrate drug combination cytochrome P450 family 4 subfamily F member 3 Homo sapiens