Title : SIRT1 mediates Sphk1/S1P-induced proliferation and migration of endothelial cells.

Pub. Date : 2016 May

PMID : 26923291






1 Functional Relationships(s)
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1 Treatment of HUVECs with PD98059, SB203580 and Wortmannin, which are the inhibitors of ERK, P38 MAPK and AKT respectively, resulted in decreased SIRT1 expression and reduced migration of HUVEC cells. Wortmannin mitogen-activated protein kinase 1 Homo sapiens