Title : Differential metabolism of 3FDT and docetaxel in RLMs, rats, and HLMs.

Pub. Date : 2016 May 4

PMID : 26922231






2 Functional Relationships(s)
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1 Our findings indicated that the major metabolic site switched from the C3" appendage for docetaxel to the taxane ring for 3FDT, and the main metabolizing P450 enzymes switched from CYP3A to CYP3A4 and CYP2E1. 3fdt cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Our findings indicated that the major metabolic site switched from the C3" appendage for docetaxel to the taxane ring for 3FDT, and the main metabolizing P450 enzymes switched from CYP3A to CYP3A4 and CYP2E1. 3fdt cytochrome P450 family 3 subfamily A member 4 Homo sapiens