Title : Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve Metabolic Stability.

Pub. Date : 2016 May

PMID : 26921388






1 Functional Relationships(s)
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1 Replacement of hydrogen with fluorine is a useful drug design strategy when decreases in cytochrome P450 (P450) metabolic lability are needed. Hydrogen cytochrome P450 family 4 subfamily F member 3 Homo sapiens