Pub. Date : 2016 Feb
PMID : 26911949
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Influence of simvastatin treatment on Toll-like receptor 4 in monocytes of peripheral blood in patients with sepsis and severe sepsis]. | Simvastatin | toll like receptor 4 | Homo sapiens |
| 2 | OBJECTIVE: To investigate the influence of simvastatin treatment on Toll-like receptor 4 (TLR4) in monocytes of peripheral blood in patients with sepsis and severe sepsis and its significance. | Simvastatin | toll like receptor 4 | Homo sapiens |
| 3 | OBJECTIVE: To investigate the influence of simvastatin treatment on Toll-like receptor 4 (TLR4) in monocytes of peripheral blood in patients with sepsis and severe sepsis and its significance. | Simvastatin | toll like receptor 4 | Homo sapiens |
| 4 | RESULTS: TLR4 expression on the surface of monocytes showed a tendency of decreasing with prolongation of simvastatin treatment in the simvastatin group in patients with sepsis (n = 59) or severe sepsis (n = 54). | Simvastatin | toll like receptor 4 | Homo sapiens |
| 5 | RESULTS: TLR4 expression on the surface of monocytes showed a tendency of decreasing with prolongation of simvastatin treatment in the simvastatin group in patients with sepsis (n = 59) or severe sepsis (n = 54). | Simvastatin | toll like receptor 4 | Homo sapiens |
| 6 | However, in patients with sepsis, TLR4 level was significantly decreased from 10 days in simvastatin group as compared with that of conventional therapy group (n = 47), and it was decreased up to 15 days [mean fluorescence intensity (MFI): 21 (19, 28) vs. 27 (25, 33) at 10 days, Z = 2.198, P = 0.021; 16 (15, 21) vs. 26 (23, 34) at 15 days, Z = 4.611, P = 0.002]. | Simvastatin | toll like receptor 4 | Homo sapiens |