Title : In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.

Pub. Date : 2016

PMID : 26910068






3 Functional Relationships(s)
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1 In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. Paclitaxel cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In this investigation, we tested the hypothesis that induction of cytochrome P450 (Cyp)3a11 gene by paclitaxel is downregulated by the inflammatory mediator, lipopolysaccharide (LPS), and that the pro-inflammatory cytokine, tumor necrosis factor (TNF)-alpha, attenuates human CYP3A4 gene induction by rifampicin. Paclitaxel cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 Induction and subsequent downregulation of CYP3A enzyme can impact paclitaxel treatment in cancer patients where inflammatory mediators are activated. Paclitaxel cytochrome P450 family 3 subfamily A member 4 Homo sapiens