Pub. Date : 2016
PMID : 26910068
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In this investigation, we tested the hypothesis that induction of cytochrome P450 (Cyp)3a11 gene by paclitaxel is downregulated by the inflammatory mediator, lipopolysaccharide (LPS), and that the pro-inflammatory cytokine, tumor necrosis factor (TNF)-alpha, attenuates human CYP3A4 gene induction by rifampicin. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Induction and subsequent downregulation of CYP3A enzyme can impact paclitaxel treatment in cancer patients where inflammatory mediators are activated. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |