Title : Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice.

Pub. Date : 2016 Aug

PMID : 26909542






4 Functional Relationships(s)
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1 Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype. Epinephrine adrenergic receptor, beta 2 Mus musculus
2 Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype. Epinephrine adrenergic receptor, beta 2 Mus musculus
3 Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype. Epinephrine adrenergic receptor, beta 2 Mus musculus
4 Based on these and other studies showing differential effects of various beta2AR ligands on the asthma phenotype, we have speculated that the permissive effect of endogenous epinephrine and exogenous beta2AR agonists on allergic lung inflammation can be explained by qualitative beta2AR signaling. Epinephrine adrenergic receptor, beta 2 Mus musculus