Title : The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1.

Pub. Date : 2016 Apr 15

PMID : 26903512






4 Functional Relationships(s)
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1 Here we show that the PIP motif of yeast polymerase eta mediates its interactions both with PCNA and with Rev1. pip deoxycytidyl transferase Saccharomyces cerevisiae S288C
2 Moreover, the PIP motif of polymerase eta binds in the hydrophobic pocket on the Rev1 C-terminal domain. pip deoxycytidyl transferase Saccharomyces cerevisiae S288C
3 We also show that the RIR motif of human polymerase kappa and the PIP motif of yeast Msh6 bind both PCNA and Rev1. pip deoxycytidyl transferase Saccharomyces cerevisiae S288C
4 Overall, these findings demonstrate that PIP motifs and RIR motifs have overlapping specificities and can interact with both PCNA and Rev1 in structurally similar ways. pip deoxycytidyl transferase Saccharomyces cerevisiae S288C