Pub. Date : 2016 Mar 27
PMID : 26903089
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The FK506 binding protein FKBP52 is able to induce oligomers in the pathogenic Tau P301L mutant and in a truncated form of the wild-type human Tau protein. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |
| 2 | We find that FKBP52 indeed can isomerize selected prolyl bonds in the different Tau proteins, and that this activity is carried solely by its first FK506 binding domain. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |
| 3 | In addition, we identified a novel molecular interaction implying the PHF6 peptide of Tau and the FK1/FK2 domains of FKBP52 independent of FK506 binding; these data point toward a non-catalytic molecular interaction that might govern the effect of FKBP52 on Tau. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |