Title : Design and Synthesis of Coumarin Derivatives as Novel PI3K Inhibitors.

Pub. Date : 2017

PMID : 26902599






2 Functional Relationships(s)
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1 Since aberrant upregulation of PI3K/Akt signaling is related to uncontrolled tumor cell proliferation, enhanced migration, and adhesion-independent tumor growth, it is of interests to find novel coumarin derivatives as anticancer agents targeting the PI3K/Akt signaling pathway. coumarin AKT serine/threonine kinase 1 Homo sapiens
2 Since aberrant upregulation of PI3K/Akt signaling is related to uncontrolled tumor cell proliferation, enhanced migration, and adhesion-independent tumor growth, it is of interests to find novel coumarin derivatives as anticancer agents targeting the PI3K/Akt signaling pathway. coumarin AKT serine/threonine kinase 1 Homo sapiens