Title : Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism.

Pub. Date : 2016 Apr 13

PMID : 26896706






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TAM is metabolized to the more active 4-hydroxytamoxifen (4-OH-TAM) and endoxifen by cytochrome P450 (CYP) mainly CYP2D6 and CYP3A4 enzymes. 4-hydroxy-N-desmethyltamoxifen cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 TAM is metabolized to the more active 4-hydroxytamoxifen (4-OH-TAM) and endoxifen by cytochrome P450 (CYP) mainly CYP2D6 and CYP3A4 enzymes. 4-hydroxy-N-desmethyltamoxifen cytochrome P450 family 4 subfamily F member 3 Homo sapiens