Title : Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis activates Akt signaling to ameliorate hepatic steatosis.

Pub. Date : 2016 Feb 17

PMID : 26883384






4 Functional Relationships(s)
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1 Here we showed that deletion of ACE2 aggravates liver steatosis, which is correlated with the increased expression of hepatic lipogenic genes and the decreased expression of fatty acid oxidation-related genes in the liver of ACE2 knockout (ACE2(-/y)) mice. Fatty Acids angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus
2 Here we showed that deletion of ACE2 aggravates liver steatosis, which is correlated with the increased expression of hepatic lipogenic genes and the decreased expression of fatty acid oxidation-related genes in the liver of ACE2 knockout (ACE2(-/y)) mice. Fatty Acids angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus
3 Here we showed that deletion of ACE2 aggravates liver steatosis, which is correlated with the increased expression of hepatic lipogenic genes and the decreased expression of fatty acid oxidation-related genes in the liver of ACE2 knockout (ACE2(-/y)) mice. Fatty Acids angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus
4 On the contrary, overexpression of ACE2 improved fatty liver in db/db mice, and the mRNA levels of fatty acid oxidation-related genes were up-regulated. Fatty Acids angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus