Title : Efficacy of tamoxifen in combination with docetaxel in patients with advanced non-small-cell lung cancer pretreated with platinum-based chemotherapy.

Pub. Date : 2016 Jun

PMID : 26882453






3 Functional Relationships(s)
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1 The combination of TXT and TAM could effectively reverse P-gp expression in tumor tissues and provide a significant survival benefit for advanced NSCLC patients compared with TXT alone (11.6 vs. 9.1 months, P=0.030). Docetaxel ATP binding cassette subfamily B member 1 Homo sapiens
2 In addition, in the TXT+TAM group, patients achieving P-gp reversal had a significantly greater median progression-free survival and overall survival than nonreversal patients. Docetaxel ATP binding cassette subfamily B member 1 Homo sapiens
3 The combination of TXT and TAM may be an effective and safe treatment option for advanced NSCLC patients who have already developed P-gp-mediated multidrug resistance. Docetaxel ATP binding cassette subfamily B member 1 Homo sapiens