Pub. Date : 2016 Apr
PMID : 26881857
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Four days of daily inhalation of ambroxol at 3.75 or 7.5mg/ml for 20 min suppressed the accumulation of neutrophils and macrophages in the bronchoalveolar lavage fluid (BALF) and lung tissues, and inhibited increases in the mRNA and protein levels of tumor necrosis factor (TNF)-alpha, CCL-2 and KC, but not interleukin (IL)-1beta in the CS-exposed mice. | Ambroxol | interleukin 1 beta | Mus musculus |
| 2 | Using cultured lung epithelial cells, we demonstrated that pretreatment with ambroxol at 2 or 20 muM inhibited the CSE-induced up-regulation of MUC5AC, TNF-alpha, IL-1beta mRNA levels, which was through inhibiting Erk signaling pathway. | Ambroxol | interleukin 1 beta | Mus musculus |