Pub. Date : 2016
PMID : 26881256
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | This study observed the expression of NLRP3 inflammasome signaling stimulated by high glucose, lipopolysaccharide, and reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine in glomerular mesangial cells, aiming to elucidate the mechanism by which the NLRP3 inflammasome signaling pathway may contribute to diabetic nephropathy. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | This study observed the expression of NLRP3 inflammasome signaling stimulated by high glucose, lipopolysaccharide, and reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine in glomerular mesangial cells, aiming to elucidate the mechanism by which the NLRP3 inflammasome signaling pathway may contribute to diabetic nephropathy. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Simultaneously, the mRNA and protein levels of TXNIP, NLRP3, procaspase-1, and IL-1beta were significantly induced by high glucose concentration and lipopolysaccharide in a dose-dependent and time-dependent manner in vitro. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Our results firstly reveal that high glucose and lipopolysaccharide activate ROS/TXNIP/ NLRP3/IL-1beta inflammasome signaling in glomerular mesangial cells, suggesting a mechanism by which inflammation may contribute to the development of diabetic nephropathy. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |