Title : Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.

Pub. Date : 2016 Feb 25

PMID : 26878238






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 As for asparagine, this observation was linked to high levels of PYCR1, a key enzyme in proline production, suggesting a compensatory mechanism allowing tumour expansion. Proline pyrroline-5-carboxylate reductase 1 Homo sapiens
2 Indeed, PYCR1 is induced by shortage of proline precursors, and its suppression attenuated kidney cancer cell proliferation when proline was limiting. Proline pyrroline-5-carboxylate reductase 1 Homo sapiens
3 Indeed, PYCR1 is induced by shortage of proline precursors, and its suppression attenuated kidney cancer cell proliferation when proline was limiting. Proline pyrroline-5-carboxylate reductase 1 Homo sapiens