Title : Combining angiotensin II receptor 1 antagonism and neprilysin inhibition for the treatment of heart failure.

Pub. Date : 2016 Apr

PMID : 26873036






1 Functional Relationships(s)
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1 PARADIGM-HF trial has proved the superiority of sacubitril/valsartan (LCZ696) over ACE inhibitor enalapril to reduce mortality and morbidity of symptomatic HF patients with reduced ejection fraction (HFrEF), setting the grounds for the replacement of ACE inhibitors by sacubitril/valsartan in the management of HFrEF. Valsartan angiotensin I converting enzyme Homo sapiens