Title : Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-κB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways.

Pub. Date : 2016 Jan

PMID : 26870201






5 Functional Relationships(s)
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1 Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-kappaB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways. psoralidin BCL2 apoptosis regulator Homo sapiens
2 Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-kappaB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways. psoralidin BCL2 apoptosis regulator Homo sapiens
3 Furthermore, psoralidin was able to reduce Bcl-2 protein expression and increase Bax protein expression in SW480 cells. psoralidin BCL2 apoptosis regulator Homo sapiens
4 Notably, Bcl-2 inhibitor was observed to enhance the effects of psoralidin on SW480 cells. psoralidin BCL2 apoptosis regulator Homo sapiens
5 The results of the present study suggest that psoralidin may be a candidate drug for the treatment of colon cancer by inhibition of the NF-kappaB and Bcl-2/Bax signaling pathways. psoralidin BCL2 apoptosis regulator Homo sapiens