Title : Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells.

Pub. Date : 2016 May

PMID : 26852666






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Addition of GAM to Muller cell culture repressed insulin-induced activation of the Akt/mTORC1 signaling pathway. Glucosamine AKT serine/threonine kinase 1 Homo sapiens
2 Instead, GAM induced ER stress and subsequent expression of the protein Regulated in DNA Damage and Development (REDD1), which was necessary for GAM to repress insulin-stimulated phosphorylation of Akt on Thr308. Glucosamine AKT serine/threonine kinase 1 Homo sapiens