Pub. Date : 2016 Jun
PMID : 26838046
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In mice, the tumor promoter phenobarbital (PB) selects for hepatocellular tumors with activating beta-catenin mutations via constitutive androstane receptor activation. | Phenobarbital | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 2 | In mice, the tumor promoter phenobarbital (PB) selects for hepatocellular tumors with activating beta-catenin mutations via constitutive androstane receptor activation. | Phenobarbital | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 3 | PB-dependent tumor promotion was studied in mice with genetic inactivation of Apc, a negative regulator of beta-catenin, to circumvent the problem of randomly induced mutations by chemical initiators and to allow monitoring of PB- and Wnt/beta-catenin-dependent tumorigenesis in the absence of unknown genomic alterations. | Phenobarbital | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 4 | PB-dependent tumor promotion was studied in mice with genetic inactivation of Apc, a negative regulator of beta-catenin, to circumvent the problem of randomly induced mutations by chemical initiators and to allow monitoring of PB- and Wnt/beta-catenin-dependent tumorigenesis in the absence of unknown genomic alterations. | Phenobarbital | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 5 | Moreover, the study was designed to investigate PB-induced proliferation of liver cells with activated beta-catenin. | Phenobarbital | catenin (cadherin associated protein), beta 1 | Mus musculus |