Title : Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice.

Pub. Date : 2016 Jun

PMID : 26838046






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In mice, the tumor promoter phenobarbital (PB) selects for hepatocellular tumors with activating beta-catenin mutations via constitutive androstane receptor activation. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus
2 In mice, the tumor promoter phenobarbital (PB) selects for hepatocellular tumors with activating beta-catenin mutations via constitutive androstane receptor activation. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus
3 PB-dependent tumor promotion was studied in mice with genetic inactivation of Apc, a negative regulator of beta-catenin, to circumvent the problem of randomly induced mutations by chemical initiators and to allow monitoring of PB- and Wnt/beta-catenin-dependent tumorigenesis in the absence of unknown genomic alterations. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus
4 PB-dependent tumor promotion was studied in mice with genetic inactivation of Apc, a negative regulator of beta-catenin, to circumvent the problem of randomly induced mutations by chemical initiators and to allow monitoring of PB- and Wnt/beta-catenin-dependent tumorigenesis in the absence of unknown genomic alterations. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus
5 Moreover, the study was designed to investigate PB-induced proliferation of liver cells with activated beta-catenin. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus