Title : Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.

Pub. Date : 2016 Jul

PMID : 26833890






1 Functional Relationships(s)
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1 Among them, 3-bromobenzylamide derivative 4m exhibited the best acetylcholinesterase inhibitory activity with IC50 value of 13 +- 1.4 nm which is 51-fold superior to galantamine, a reference drug. 3-bromobenzylamide acetylcholinesterase (Cartwright blood group) Homo sapiens