Pub. Date : 2016 Apr 19
PMID : 26824324
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibits 17beta-estradiol-induced epithelial-to-mesenchymal transition via betaKlotho-related ERK1/2 signaling and AMPKalpha signaling in endometrial adenocarcinoma cells. | Metformin | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | In addition, metformin increased the expression of betaKlotho, a fibroblast growth factors (FGFs) coreceptor, and decreased ERK1/2 phosphorylation in both Ishikawa and KLE cells. | Metformin | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | In conclusion, metformin abolishes 17beta-estradiol-induced cell proliferation and EMT in endometrial adenocarcinoma cells by upregulating betaKlotho expression, inhibiting ERK1/2 signaling, and activating AMPKalpha signaling. | Metformin | mitogen-activated protein kinase 3 | Homo sapiens |