Pub. Date : 2016 Apr 15
PMID : 26819452
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. | isocitric acid | isocitrate dehydrogenase (NADP(+)) 2 | Homo sapiens |
| 2 | IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. | isocitric acid | isocitrate dehydrogenase (NADP(+)) 2 | Homo sapiens |