Title : Nestin-positive/SOX2-negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice.

Pub. Date : 2016 Feb 26

PMID : 26806039






1 Functional Relationships(s)
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1 This system utilizes transgenic mice that express a tamoxifen-activatable Cre recombinase (Cre(ERT2)) under the control of the neuronal progenitor cell promoters nestin or Sox2 leading to suppression of the DA neuron marker tyrosine hydroxylase (TH) via excision of exon 1 by flanking loxP sites in adult animals. Tamoxifen mitogen-activated protein kinase 3 Mus musculus