Title : High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model.

Pub. Date : 2016 Feb 23

PMID : 26802022






2 Functional Relationships(s)
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1 The results demonstrated that metformin activated AMPK and decreased phosphorylation of Akt and Erk. Metformin mitogen-activated protein kinase 1 Homo sapiens
2 Furthermore, combinations of metformin with either Akt or Erk inhibitors synergistically diminished cancer proliferation, suggesting the involvement of Akt- and Erk- related pathways. Metformin mitogen-activated protein kinase 1 Homo sapiens