Pub. Date : 2016 Apr
PMID : 26801320
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of heme oxygenase-1 enhances the chemosensitivity of laryngeal squamous cell cancer Hep-2 cells to cisplatin. | Cisplatin | heme oxygenase 1 | Homo sapiens |
| 2 | In this research we proved that cisplatin induced cell injuries and heme oxygenase-1 (HO-1) expression in laryngeal squamous cell cancer Hep-2 cells through ROS generation. | Cisplatin | heme oxygenase 1 | Homo sapiens |
| 3 | In this research we proved that cisplatin induced cell injuries and heme oxygenase-1 (HO-1) expression in laryngeal squamous cell cancer Hep-2 cells through ROS generation. | Cisplatin | heme oxygenase 1 | Homo sapiens |
| 4 | The induction of HO-1 clearly protected Hep-2 cells from cisplatin-induced cell death and ROS reaction, and the inhibitor of HO-1 enhanced the cell death and ROS generation induced by cisplatin. | Cisplatin | heme oxygenase 1 | Homo sapiens |
| 5 | The induction of HO-1 clearly protected Hep-2 cells from cisplatin-induced cell death and ROS reaction, and the inhibitor of HO-1 enhanced the cell death and ROS generation induced by cisplatin. | Cisplatin | heme oxygenase 1 | Homo sapiens |
| 6 | Furthermore, the HO-1 expression induced by cisplatin was strongly inhibited by the knockdown of nuclear factor-erythroid-2-related factor-2 (Nrf-2), and the oxidative damages induced by cisplatin were significantly enhanced. | Cisplatin | heme oxygenase 1 | Homo sapiens |
| 7 | Furthermore, the HO-1 expression induced by cisplatin was strongly inhibited by the knockdown of nuclear factor-erythroid-2-related factor-2 (Nrf-2), and the oxidative damages induced by cisplatin were significantly enhanced. | Cisplatin | heme oxygenase 1 | Homo sapiens |
| 8 | Therefore, it may be concluded that the inhibition of HO-1 or the knockdown of Nrf-2 significantly enhanced cisplatin"s anticancer effects on Hep-2 cells. | Cisplatin | heme oxygenase 1 | Homo sapiens |
| 9 | In clinic, with the overexpression of HO-1 in laryngeal squamous cancer tissues, the combination of cisplatin with the inhibitor of HO-1 or Nrf-2 siRNA may act as a new method to the treatment of laryngeal squamous cancer. | Cisplatin | heme oxygenase 1 | Homo sapiens |
| 10 | In clinic, with the overexpression of HO-1 in laryngeal squamous cancer tissues, the combination of cisplatin with the inhibitor of HO-1 or Nrf-2 siRNA may act as a new method to the treatment of laryngeal squamous cancer. | Cisplatin | heme oxygenase 1 | Homo sapiens |